Recent Publications

Alvarez Pub FigureNRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.
Nature Metabolism 2020 Apr;2(4): 318-334
https://pubmed.ncbi.nlm.nih.gov/32691018/

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Counter Pub Figure 2Capturing the primordial Kras mutation initiating urethane carcinogenesis.
Nature Communications 2020 Apr 14;11(1):1800
https://pubmed.ncbi.nlm.nih.gov/32286309/

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Goetz Pub FiguresTTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
eLife 2020;9:e51166
https://pubmed.ncbi.nlm.nih.gov/31934864/

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Haystead Pub FigureTAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades.
Oncotarget 2020; 11:1961-1970
https://pubmed.ncbi.nlm.nih.gov/32523651/

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Lew Pub FigureMechanistic insights into actin-driven polarity site movement in yeast.
Mol. Biol. Cell 2020; 31(10):1085-1102
https://pubmed.ncbi.nlm.nih.gov/32186970/

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Locasale Pub FigureHistone lactylation: A new role for glucose metabolism.
Trends Biochem. Sci. 2020; 45(3):179-182
https://pubmed.ncbi.nlm.nih.gov/31901298/
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McDonnell Pub FigurePharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen-receptor alpha degrader activity in anti tumor efficacy.
Breast Cancer Res. Treat. 2020; 179(1):67-77
https://pubmed.ncbi.nlm.nih.gov/31562570/
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Identification of a small molecule that stimulates human beta-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
PLoS One 2020; 15(3):e0224344
https://pubmed.ncbi.nlm.nih.gov/32176701/
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Slotkin Pub FigurePaternal delta9-tetrahydrocannabinol exposure prior to mating elicits deficits in cholinergic synaptic function in the offspring.
Toxicological Sciences 2020; 174(2):210-217
https://pubmed.ncbi.nlm.nih.gov/32077955/
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Tsvetanova Pub FigureA high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.
bioRxiv 2020.09.02.279679
https://doi.org/10.1101/2020.09.02.279679

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VanDongen Pub FigureFamiliarity detection and memory consolidation in cortical assemblies.
eNeuro 2020; 7(3):ENEURO.0006-19.2020
https://pubmed.ncbi.nlm.nih.gov/32122957/
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West Research imageLRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
EMBO J 2020; Aug 27;e104862
https://pubmed.ncbi.nlm.nih.gov/32853409/
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Wingler Pub FigureAngiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
Science 2020; 367(6480):888-892
https://pubmed.ncbi.nlm.nih.gov/32079768/
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Wood Pub FigureUsing antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.
Nature Genetics 2020 Apr;52(4):408-417
https://pubmed.ncbi.nlm.nih.gov/32203462/