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Armstrong, Andrew

Andrew ArmstrongAssociate Professor of Medicine

Email: andrew.armstrong@duke.edu
More Information

Dr. Armstrong’s research is focused on 1) predictive biomarker development in prostate cancer using circulating biomarkers including circulating tumor cells and cell free DNA; 2) experimental therapeutics development through clinical trials and pre-clinical studies of drug discovery and resistance in prostate cancer; and 3) investigating the role of epithelial plasticity in mediating prostate cancer metastasis and treatment resistance in patients and preclinical model systems.

Arshavsky, Vadim

Vadim ArshavksyHelena Rubinstein Foundation Professor of Ophthalmology

Email: vadim.arshavsky@duke.edu
Lab Website

Cell biology and pathophysiology of vertebrate photoreceptors.

 

Blobe, Gerard

Gerard BlobeAssociate Professor of Medicine

Email: gerard.blobe@duke.edu
Lab Website

Our laboratory focuses on the role of transforming growth factor-ß (TGF-ß) superfamily signal transduction pathways in cancer biology.

 

Campbell, Jonathan
Jonathan Campbell

Associate Professor of Medicine

Email: jonathan.campbell@duke.edu
DMPI Website

Our group studies the impact of gut peptides (GIP, GLP-1, glucagon) on islet function and glucose homeostasis, in the context of health, diabetes, obesity, and bariatric surgery models.

Chi, Ashley

Ashley ChiAssociate Professor in Molecular Genetics and Microbiology

Email: jentsan.chi@duke.edu

We are using functional genomic approaches to determine how tumor cells adapt to tumor microenvironmental stresses.

 

Floyd, Scott R.

Scott FloydAssociate Professor of Radiation Oncology

Email: scott.floyd@duke.edu
Lab Website

Our lab focuses on studying mechanisms of DNA damage signaling and repair in human and other mammalian cells. Acquiring deeper knowledge on how cancer cells repair DNA damage, or lack of such capabilities thereof, can lead to improved cancer treatments in the clinic.

Gurley, Susan Bailey

Susan GurleyAssociate Professor of Medicine

Email: susan.gurley@duke.edu
Lab Website

The Gurley lab uses mouse models of human disease to understand pathophysiology and identify new treatment targets.  Areas of interest include diabetic kidney disease and hypertension.

Heitman, Joseph

Joseph HeitmanChair, Department of Molecular Genetics and Microbiology

Email: joseph.heitman@duke.edu
Faculty Page

Our research program focuses on: 1)  the evolution of sexual reproduction and its impact on eukaryotic microbial pathogens, 2) the structure, function, and evolution of mating type loci and determinants as models for gene cluster and sex chromosome evolution, and 3) the targets and mechanisms of action of immunosuppressive, anti-fungal, cancer chemotherapy drugs (rapamycin, FK506, cyclosporin A) including the pharmacological and biological roles of FKBP12, calcineurin, and TOR.

Herman, Mark A.

Mark HermanAssistant Professor of Medicine

Email: mark.herman@duke.edu
Faculty Page

The Herman lab investigates the role of cellular nutrient sensing mechanisms in cardiometabolic health and disease.

 

Hirschey, Matthew

Matthew HirscheyAssociate Professor in Medicine

Email: matthew.hirschey@duke.edu
Lab Website

The Hirschey Lab studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.

 

Hong, Jiyong

Jiyong HongProfessor of Chemistry

Email: jiyong.hong@duke.edu
Lab Website

Research in the Hong group focuses on using chemical tools, in particular small molecules, to understand the signaling pathways in biology.

 

Huang, Jiaoti

Jiaoti HuangProfessor and Chairman, Department of Pathology

Email: jiaoti.huang@duke.edu
Lab Website

Our lab’s research focuses on prostate cancer including molecular mechanisms of carcinogenesis, therapeutic resistance and disease progression. We are particularly interested in biomarkers, imaging and novel treatment strategies.

Kirsch, David G.

David KirschProfessor and Vice Chair for Basic & Translational Research
Department of Radiation Oncology

Email: david.kirsch@duke.edu
Lab Website

We use genetically engineered mouse models to study cancer development, metastasis, and response to radiation therapy as well as normal tissue toxicity following radiation exposure.

Kontos, Christopher

Christopher KontosAssociate Professor of Medicine

Email: chris.kontos@duke.edu
Lab Website

Molecular mechanisms of vascular remodeling in cardiovascular diseases, including tumor angiogenesis, with emphasis on signaling by endothelial receptor tyrosine kinases.

Kwatra, Madan

Madan KwatraAssociate Professor in Anesthesiology

Email: madan.kwatra@duke.edu
Lab Website

Personalized drug development for glioblastoma.

 

Levin, Ed

Ed LevinProfessor in Psychiatry and Behavioral Sciences

Email: edlevin@duke.edu
Faculty Page

Dr. Levin investigates the neurobehavioral toxicology of development and the neural basis of addictive behavior. He focuses on how neural toxicants impair behavior and how therapeutics can be developed to reverse behavioral dysfunction.

Li, Chuan-Yuan

Chuan-Yuan LiProfessor of Dermatology

Email: chuan.li@duke.edu
Lab Website

Non-canonical roles of cell death factors and DNA damage repair proteins in carcinogenesis, cancer treatment, and stem cell regulation.

 

Linardic, Corinne M.

Corinne LinardicAssociate Professor of Pediatrics

Email: corinne.linardic@duke.edu
Faculty Page

We investigate the molecular mechanisms underlying rhabdomyosarcoma, a childhood cancer of skeletal muscle origin. Emphasis is on understanding the contribution of rhabdomyosarcoma-specific gene mutations to tumor formation, and how they can be targeted therapeutically.

MacIver, Nancie

Nancie MacIverAssociate Professor of Pediatrics

Email: nancie.maciver@duke.edu

The MacIver laboratory is broadly interested in how large changes in nutritional status (e.g. malnutrition or obesity) influence T cell immunity.

 

McNamara, James

James McNamaraProfessor in Neuroscience

Email: jmc@neuro.duke.edu
Lab Website

Epilepsy; molecular studies of kindling; gene regulation by excitatory amino acid neurotransmitters.

 

Miller, Francis

Francis MillerProfessor of Medicine

Email: francis.miller@duke.edu

Our lab utilizes cultured cells, animal models, and patient samples to understand the redox-dependent mechanisms and identify potential therapeutic targets in vascular disease.

 

Muoio, Deb

Deb MuoioProfessor of Medicine

Email: debbie.muoio@duke.edu
Faculty Page

Our lab studies molecular mechanisms that link lifestyle factors such as nutrition and exercise to mitochondrial function and metabolic health.

 

Patierno, Steven

Steven PatiernoProfessor of Medicine

Email: steven.patierno@duke.edu

Molecular and cellular biology of prostate cancer.  Genomics, epigenomics, transcriptomics, proteomics and metabolomics of prostate cancer disparities.  Understanding the molecular and cellular biology of race-related differences in prostate cancer aggressiveness, with particular emphasis on alternative RNA splicing. Identification of novel molecular biomarkers (functional SNPs) and therapeutic targets for aggressive prostate cancer and development of RNA therapeutics.

Patz, Edward

Edward PatzJames and Alice Chen Professor of Radiology

Email: edward.patz@duke.edu
Faculty Page

Molecular oncology, pharmacology and targeted experimental therapeutics. Genomics of cancer disparities, alternative splicing, and signaling pathways associated with tumor aggressiveness. Molecular carcinogenesis and cell death/survival signaling after DNA damage.

Ramanujam, Nimmi

Nimmi RamanujamRobert W. Carr, Jr., Professor of Biomedical Engineering

Email: nimmi.ramanujam@duke.edu
Faculty Page

Multi-disciplinary translational research program focused on the development of novel optical technologies for noninvasive or minimally invasive assessment of women’s health and in particular, breast and cervical cancer.

Rao, Vasantha

Vasntha RaoProfessor of Ophthalmology

Email: p.rao@duke.edu

Our research is broadly focused on investigating the role of actin cytoskeletal biology and cell adhesive mechanisms in ocular lens and trabecular meshwork function and pathobiology.

 

Sipkins, Dorothy A.

Dorothy SipkinsAssociate Professor of Medicine

Email: dorothy.sipkins@duke.edu
Lab Website

My lab studies how tumor cells hijack normal hematopoietic stem cell niches to travel in, out and through the bone marrow and to evade chemotherapy. We utilize real-time, single cell resolution assays including intravital confocal and dual photon microscopy to study these processes in mouse models of leukemia and breast cancer. We are actively developing early phase clinical trials to both test our pre-clinical findings in patient populations and further investigate these molecular mechanisms in humans.

Spector, Neil

Neil SpectorSandra Coates Associate Professor of Medicine

Email: neil.spector@duke.edu
Faculty Page

The fundamental role of the HER receptor signaling network in solid tumor oncogenesis and development of HER targeted therapeutic strategies.

 

Sullenger, Bruce

Bruce SullengerJoseph W. and Dorothy W. Beard Professor of Experimental Surgery

Email: bruce.sullenger@duke.edu
Faculty Page

Translational research applications of RNA therapeutics.

 

Yan, Hai

Hai YanHenry S. Friedman Professor of Neuro-Oncology

Email: hai.yan@duke.edu
Lab Website

Noted for our seminal discoveries of IDH1/2, ATRX and TERT mutations, which form the basis for the classification of gliomas, provide more accurate diagnostic and prognostic information, enable personalized therapy and  tailored clinical trials, and provide a new understanding of gliomagenesis.