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Armstrong, Andrew
Professor of Medicine
Email: andrew.armstrong@duke.edu
More Information
Dr. Armstrong’s research is focused on 1) predictive biomarker development in prostate cancer using circulating biomarkers including circulating tumor cells and cell free DNA; 2) experimental therapeutics development through clinical trials and pre-clinical studies of drug discovery and resistance in prostate cancer; and 3) investigating the role of epithelial plasticity in mediating prostate cancer metastasis and treatment resistance in patients and preclinical model systems.
Arshavsky, Vadim
Helena Rubinstein Foundation Professor of Ophthalmology
Email: vadim.arshavsky@duke.edu
Lab Website
Cell biology and pathophysiology of vertebrate photoreceptors.
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Bissig, Karl-Dimiter
Instructor, Department of Pediatrics
Email: karldimiter.bissig@duke.edu
Lab Website
We are interested in experimental therapies for the liver ranging from inborn errors of metabolism to viral hepatitis. We use human liver chimeric mice and CRISPR gene editing in vivo.
Blobe, Gerard
Professor of Medicine
Email: gerard.blobe@duke.edu
Lab Website
Our laboratory focuses on the role of transforming growth factor-ß (TGF-ß) superfamily signal transduction pathways in cancer biology.
Campbell, Jonathan
Associate Professor of Medicine
Email: jonathan.campbell@duke.edu
DMPI Website
Our group studies the impact of gut peptides (GIP, GLP-1, glucagon) on islet function and glucose homeostasis, in the context of health, diabetes, obesity, and bariatric surgery models.
Chi, Ashley
Associate Professor in Molecular Genetics and Microbiology
Email: jentsan.chi@duke.edu
We are using functional genomic approaches to determine how tumor cells adapt to tumor microenvironmental stresses.
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Floyd, Scott R.
Associate Professor of Radiation Oncology
Email: scott.floyd@duke.edu
Lab Website
Our lab focuses on studying mechanisms of DNA damage signaling and repair in human and other mammalian cells. Acquiring deeper knowledge on how cancer cells repair DNA damage, or lack of such capabilities thereof, can lead to improved cancer treatments in the clinic.
Hanks, Brent A.
Assistant Professor of Medicine
Email: brent.hanks@duke.edu
Lab Website
Our laboratory utilizes transgenic murine tumor models and clinical specimens to investigate the cellular and molecular interplay between developing malignancies and the immune microenvironment in an effort to better understand the active mechanisms by which cancers mediate immune evasion and promote immunotherapy resistance. Current efforts are focused on examining the role of the Wnt-beta-catenin signaling pathway and the process of EMT in the induction of dendritic cell tolerization and myeloid-derived suppressor cell recruitment.
Heitman, Joseph
Chair, Department of Molecular Genetics and Microbiology
Email: joseph.heitman@duke.edu
Faculty Page
Our research program focuses on: 1) the evolution of sexual reproduction and its impact on eukaryotic microbial pathogens, 2) the structure, function, and evolution of mating type loci and determinants as models for gene cluster and sex chromosome evolution, and 3) the targets and mechanisms of action of immunosuppressive, anti-fungal, cancer chemotherapy drugs (rapamycin, FK506, cyclosporin A) including the pharmacological and biological roles of FKBP12, calcineurin, and TOR.
Herman, Mark A.
Associate Professor of Medicine
Email: mark.herman@duke.edu
Faculty Page
The Herman lab investigates the role of cellular nutrient sensing mechanisms in cardiometabolic health and disease.
Hirschey, Matthew
Professor in Medicine
Email: matthew.hirschey@duke.edu
Lab Website
The Hirschey Lab studies different aspects of metabolic control, mitochondrial signaling, and cellular processes regulating human health and disease.
Hong, Jiyong
Professor of Chemistry
Email: jiyong.hong@duke.edu
Lab Website
Research in the Hong group focuses on using chemical tools, in particular small molecules, to understand the signaling pathways in biology.
Huang, Jiaoti
Professor and Chairman, Department of Pathology
Email: jiaoti.huang@duke.edu
Lab Website
Our lab’s research focuses on prostate cancer including molecular mechanisms of carcinogenesis, therapeutic resistance and disease progression. We are particularly interested in biomarkers, imaging and novel treatment strategies.
Jordt, Sven-Eric
Associate Professor, Department of Anesthesiology
Email: sven.jordt@duke.edu
Lab Website
The Jordt lab studies the mechanisms that enable humans and animals to sense touch, pain and irritation, and how these signals are integrated by the nervous system to control defensive responses and behavior. Projects focus on receptors and the plasticity of the sensory nervous system, on therapeutic approaches for conditions such as asthma and lung injury and on how sensory perceptions affect addiction behavior.
Kirsch, David G.
Professor and Vice Chair for Basic & Translational Research
Department of Radiation Oncology
Email: david.kirsch@duke.edu
Lab Website
We use genetically engineered mouse models to study cancer development, metastasis, and response to radiation therapy as well as normal tissue toxicity following radiation exposure.
Kontos, Christopher
Professor of Medicine
Email: chris.kontos@duke.edu
Lab Website
Molecular mechanisms of vascular remodeling in cardiovascular diseases, including tumor angiogenesis, with emphasis on signaling by endothelial receptor tyrosine kinases.
Kwatra, Madan
Associate Professor in Anesthesiology
Email: madan.kwatra@duke.edu
Lab Website
Personalized drug development for glioblastoma.
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Levin, Ed
Professor in Psychiatry and Behavioral Sciences
Email: edlevin@duke.edu
Faculty Page
Dr. Levin investigates the neurobehavioral toxicology of development and the neural basis of addictive behavior. He focuses on how neural toxicants impair behavior and how therapeutics can be developed to reverse behavioral dysfunction.
Li, Chuan-Yuan
Professor of Dermatology
Email: chuan.li@duke.edu
Lab Website
Non-canonical roles of cell death factors and DNA damage repair proteins in carcinogenesis, cancer treatment, and stem cell regulation.
Linardic, Corinne M.
Associate Professor of Pediatrics
Email: corinne.linardic@duke.edu
Faculty Page
We investigate the molecular mechanisms underlying rhabdomyosarcoma, a childhood cancer of skeletal muscle origin. Emphasis is on understanding the contribution of rhabdomyosarcoma-specific gene mutations to tumor formation, and how they can be targeted therapeutically.
MacIver, Nancie
Associate Professor of Pediatrics
Email: nancie.maciver@duke.edu
The MacIver laboratory is broadly interested in how large changes in nutritional status (e.g. malnutrition or obesity) influence T cell immunity.
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McNamara, James
Professor in Neuroscience
Email: jmc@neuro.duke.edu
Lab Website
Epilepsy; molecular studies of kindling; gene regulation by excitatory amino acid neurotransmitters.
Miller, Francis
Professor of Medicine
Email: francis.miller@duke.edu
Our lab utilizes cultured cells, animal models, and patient samples to understand the redox-dependent mechanisms and identify potential therapeutic targets in vascular disease.
Muoio, Deb
Professor of Medicine
Email: debbie.muoio@duke.edu
Faculty Page
Our lab studies molecular mechanisms that link lifestyle factors such as nutrition and exercise to mitochondrial function and metabolic health.
Nackley, Andrea
Associate Professor in Anesthesiology
Email: andrea.nackley@duke.edu
Lab Website
The Nackley Lab applies a translational approach to the study of chronic pain conditions. By marrying pain neurobiology, behavioral pharmacology, and molecular genetics with clinical epidemiology, we seek to bridge the gap that exists between basic science and clinical research in order to determine factors that drive maladaptive chronic pain and identify better treatment strategies.
Patierno, Steven
Professor of Medicine
Email: steven.patierno@duke.edu
Molecular and cellular biology of prostate cancer. Genomics, epigenomics, transcriptomics, proteomics and metabolomics of prostate cancer disparities. Understanding the molecular and cellular biology of race-related differences in prostate cancer aggressiveness, with particular emphasis on alternative RNA splicing. Identification of novel molecular biomarkers (functional SNPs) and therapeutic targets for aggressive prostate cancer and development of RNA therapeutics.
Patz, Edward
James and Alice Chen Professor of Radiology
Email: edward.patz@duke.edu
Faculty Page
Molecular oncology, pharmacology and targeted experimental therapeutics. Genomics of cancer disparities, alternative splicing, and signaling pathways associated with tumor aggressiveness. Molecular carcinogenesis and cell death/survival signaling after DNA damage.
Ramanujam, Nimmi
Robert W. Carr, Jr. Professor of Biomedical Engineering
Email: nimmi.ramanujam@duke.edu
Faculty Page
Multi-disciplinary translational research program focused on the development of novel optical technologies for noninvasive or minimally invasive assessment of women’s health and in particular, breast and cervical cancer.
Rao, Vasantha
Professor of Ophthalmology
Email: p.rao@duke.edu
Our research is broadly focused on investigating the role of actin cytoskeletal biology and cell adhesive mechanisms in ocular lens and trabecular meshwork function and pathobiology.
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Roper, Jatin
Assistant Professor of Medicine
Email: jatin.roper@duke.edu
Lab Website
Our laboratory is interested in studying how stem cells in the intestine are regulated by organismal diet, the immune system, and the gut microbiome. We seek to understand how stem cell behavior regulates the development of colorectal cancer, and the progression of cancer to metastasis.
Shen, Xiling
Associate Professor of Biomedical Engineering
Email: xiling.shen@duke.edu
Lab Website
Dr. Shen’s research interests lie at precision medicine and systems biology. His lab integrates engineering, computational and biological techniques to study cancer, stem cells, microbiota and the gut-brain axis. This multidisciplinary work has been instrumental in initiating innovative translational clinical trials in precision cancer therapy.
Sipkins, Dorothy A.
Associate Professor of Medicine
Email: dorothy.sipkins@duke.edu
Lab Website
My lab studies how tumor cells hijack normal hematopoietic stem cell niches to travel in, out and through the bone marrow and to evade chemotherapy. We utilize real-time, single cell resolution assays including intravital confocal and dual photon microscopy to study these processes in mouse models of leukemia and breast cancer. We are actively developing early phase clinical trials to both test our pre-clinical findings in patient populations and further investigate these molecular mechanisms in humans.
Sullenger, Bruce
Joseph W. and Dorothy W. Beard Professor of Experimental Surgery
Email: bruce.sullenger@duke.edu
Faculty Page
Translational research applications of RNA therapeutics.
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White, Phillip
Assistant Professor in Medicine
Email: phillip.white@duke.edu
Lab Website
Our lab studies the molecular networks involved in cardiometabolic disease pathogenesis with an emphasis on defining mechanisms responsible for perturbations in glucose, lipid, and amino acid homeostasis.
Wu, Colleen
Assistant Professor in Orthopaedic Surgery
Email: colleen.wu@duke.edu
Faculty Page
The Wu lab investigates the contribution of hypoxia/HIF signaling in regulating metastatic colonization of the bone, skeletal stem cell lineage commitment, and marrow adipose tissue formation.
Yan, Hai
Henry S. Friedman Professor of Neuro-Oncology
Email: hai.yan@duke.edu
Lab Website
Noted for our seminal discoveries of IDH1/2, ATRX and TERT mutations, which form the basis for the classification of gliomas, provide more accurate diagnostic and prognostic information, enable personalized therapy and tailored clinical trials, and provide a new understanding of gliomagenesis.